The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 28, 2010
Filed:
Jun. 04, 2007
Maria-jesus Blanco-pillado, Indianapolis, IN (US);
Dana Rae Benesh, Westfield, IN (US);
Maria-Jesus Blanco-Pillado, Indianapolis, IN (US);
Dana Rae Benesh, Westfield, IN (US);
Eli Lilly and Company, Indianapolis, IN (US);
Abstract
The present invention relates to compounds of formula I: or a pharmaceutically acceptable acid addition salt thereof, wherein X is C(R3)═ or N═; Ris C-Calkyl, substituted C-Calkyl, C-Ccycloalkyl, substituted C-Ccycloalkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; Ris hydrogen, C-Cn-alkyl, C-Ccycloalkyl-C-Calkyl, or a group of formula II provided that when Ris C-Calkyl or substituted C-Calkyl, Ris hydrogen or methyl; R, Rand, when X is —C(R)═, R, are each independently hydrogen, fluoro, or methyl, provided that no more than one of R, R, and Rmay be other than hydrogen; Ris hydrogen or C-Calkyl; Ris hydrogen, C-Calkyl, or C-Ccycloalkylcarbonyl, provided that when Ris other than hydrogen, Ris hydrogen; Ris hydrogen or C-Calkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5HTreceptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal.