The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 28, 2010
Filed:
Aug. 20, 2007
Laurie E. Comstock, Medfield, MA (US);
Katja G. Weinacht, Denzlingen, DE;
Michael J. Coyne, North Attleboro, MA (US);
Dennis L. Kasper, Charlestown, MA (US);
Arthur O. Tzianabos, Reading, MA (US);
Laurie E. Comstock, Medfield, MA (US);
Katja G. Weinacht, Denzlingen, DE;
Michael J. Coyne, North Attleboro, MA (US);
Dennis L. Kasper, Charlestown, MA (US);
Arthur O. Tzianabos, Reading, MA (US);
The Brigham and Woman's Hospital, Inc., Boston, MA (US);
Abstract
The present invention is directed to methods for producing and selecting new mutant strains ofthat constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the new mutant strains ofthat constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to new res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.