The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 28, 2010
Filed:
Jan. 24, 2003
Annamari Ranki, Helsinki, FI;
Leena Karenko, Helsinki, FI;
Marketta Kähkönen, Tampere, FI;
Ritva Karhu, Tampere, FI;
Tapio Visakorpi, Tampere, FI;
Boguslaw Nedoszytko, Gdansk, PL;
Annamari Ranki, Helsinki, FI;
Leena Karenko, Helsinki, FI;
Marketta Kähkönen, Tampere, FI;
Ritva Karhu, Tampere, FI;
Tapio Visakorpi, Tampere, FI;
Boguslaw Nedoszytko, Gdansk, PL;
Helsingin Yliopiston Rahastot, Helsinki, FI;
Abstract
The present invention relates to novel methods for the diagnosis and therapy of lymphoproliferative diseases. Specifically, the present invention relates to novel methods for the diagnosis and therapy taking advantage of the detection of chromosomal breakpoints in chromosome 12 and/or translocation of chromosomal material from chromosome 12, said chromosomal breakpoints and/or translocation(s) being associated with lymphoproliferative diseases, such as primary cutaneous T-cell lymphomas (CTCL). The present invention further relates to the use of neuron navigator 3 gene (NAV3) or an equivalent or functional fragment thereof involved in chromosomal breakpoints in chromosome 12 and/or translocations thereof, said gene and/or translocations thereof being associated with lymphoproliferative diseases, such as primary cutaneous T-cell lymphomas (CTCL), as a diagnostic and therapeutic agent. The present invention also relates to the development of therapy.