The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 21, 2010
Filed:
Dec. 29, 2005
Jaeheon Lee, Yongin-si, KR;
Gha Seung Park, Yongin-si, KR;
Moonsub Lee, Daejeon, KR;
Hyo-jeong Bang, Gunpo-si, KR;
Jae Chul Lee, Suwon-si, KR;
Cheol Kyong Kim, Suwon-si, KR;
Chang-ju Choi, Seoul, KR;
Han Kyong Kim, Yongin-si, KR;
Hoe Chul Lee, Yongin-si, KR;
Young-kil Chang, Seoul, KR;
Gwan Sun Lee, Seoul, KR;
Jaeheon Lee, Yongin-si, KR;
Gha Seung Park, Yongin-si, KR;
Moonsub Lee, Daejeon, KR;
Hyo-Jeong Bang, Gunpo-si, KR;
Jae Chul Lee, Suwon-si, KR;
Cheol Kyong Kim, Suwon-si, KR;
Chang-Ju Choi, Seoul, KR;
Han Kyong Kim, Yongin-si, KR;
Hoe Chul Lee, Yongin-si, KR;
Young-Kil Chang, Seoul, KR;
Gwan Sun Lee, Seoul, KR;
Hanmi Pharm. Co., Ltd, Kyungki-do, KR;
Abstract
Provided is an improved method for stereoselectively preparing 2'-deoxy-2′,2′-difluorocytidine of formula (I), which includes reacting a 1-halo ribofuranose compound with a nucleobase of formula (IV) in a solvent to obtain a nucleo side of formula (II) with removal of a silyl halide ((alkyl)SiX (X=halide)); and deprotecting the nucleoside of formula (II) to obtain 2′-deoxy-2′,2′-difluorocytidine of formula (I). 2′-Deoxy-2′,2′-difluorocytidine of formula (I) is effective for treating various cancers such as non-small cell lung (NSCLC), pancreatic, bladder, breast or ovarian cancers.