The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 21, 2010
Filed:
Feb. 22, 2007
Ronald Breslow, Englewood, NJ (US);
Thomas A. Miller, Brookline, MA (US);
Sandro Belvedere, New York, NY (US);
Paul A. Marks, Washington, CT (US);
Victoria M. Richon, Wellesley, MA (US);
Richard A. Rifkind, New York, NY (US);
Ronald Breslow, Englewood, NJ (US);
Thomas A. Miller, Brookline, MA (US);
Sandro Belvedere, New York, NY (US);
Paul A. Marks, Washington, CT (US);
Victoria M. Richon, Wellesley, MA (US);
Richard A. Rifkind, New York, NY (US);
The Trustees of Columbia University in the City of New York, New York, NY (US);
Sloan-Kettering Institute for Cancer Research, New York, NY (US);
Abstract
The present invention relates to a novel class of hydroxamic acid derivatives having at least two aryl containing groups, at least one of which is a quinolinyl, isoquinolinyl or benzyl moiety, linked to the hydroxamic acid group through a methylene chain. The hydroxamic acid compounds can be used to treat cancer, for example, brain cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases.