The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 21, 2010
Filed:
Jul. 13, 2005
Raymond J. Andersen, Vancouver, CA;
Alban Pereira, Vancouver, CA;
Xin-hui Huang, Vancouver, CA;
Grant Mauk, Vancouver, CA;
Eduardo Vottero, Vancouver, CA;
Michel Roberge, Vancouver, CA;
Aruna Balgi, Vancouver, CA;
Raymond J. Andersen, Vancouver, CA;
Alban Pereira, Vancouver, CA;
Xin-Hui Huang, Vancouver, CA;
Grant Mauk, Vancouver, CA;
Eduardo Vottero, Vancouver, CA;
Michel Roberge, Vancouver, CA;
Aruna Balgi, Vancouver, CA;
The University of British Columbia, Vancouver, British Columbia, CA;
Abstract
Inhibitors of indoleamine 2,3-dioxygenase (IDO) are provided as are pharmaceutical compositions containing such inhibitors as well as the use of such inhibitors and compositions for the treatment of a condition in a mammalian subject characterized by pathology of the IDO-mediated tryptophan metabolic pathway. Such conditions may involve suppression of T-cell mediated immune response or may directly result from depletion of tryptophan or accumulation of a product of tryptophan degradation. Specific disease conditions include cataracts, age-related yellowing in the eye, neurodegenerative disorders, mood disorders, cancer and various bacterial/viral infections. IDO inhibitors of this invention are substituted naphthalene and anthracene diones. Novel compounds of this invention include the following taurine-substituted naphthaquinone structure.