The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 21, 2010
Filed:
Mar. 08, 2006
Applicants:
Gustav E. Lienhard, Hanover, NH (US);
Susan Kane, Beverly, MA (US);
Cristinel P. Miinea, Whitehall, PA (US);
Hiroyuki Sano, Hanover, NH (US);
Inventors:
Gustav E. Lienhard, Hanover, NH (US);
Susan Kane, Beverly, MA (US);
Cristinel P. Miinea, Whitehall, PA (US);
Hiroyuki Sano, Hanover, NH (US);
Assignee:
Trustees of Dartmouth College, Hanover, NH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/34 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention is a method for identifying agents that modulate the GTPase activity of AS160. In the instant assay, AS160 or the GAP domain thereof is contacted with a test agent, in the presence of GTP-bound Rab (2A, 8A, 8B, 10, or 14), and the AS160 GAP domain-mediated hydrolysis of GTP to GDP is monitored.