The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 21, 2010
Filed:
Oct. 01, 2003
Maik Kindermann, Basel, CH;
Kai Johnsson, Lausanne, CH;
Christoph Bieri, Basel, CH;
Ecole Polytechnique Ferdeale de Lausanne, Lausanne, CH;
Abstract
The invention relates to compounds of formula 1 wherein R-Ris a guanine derivative; X is oxygen or sulfur; Ris a heteroaromatic, unsaturated heterocyclyl or an alkynyl group with the double or triple bond connected to CH; Ris a linker; and L is a label, a plurality of same or different labels, a bond connecting Rto Rforming a cyclic substrate, or a further group —R—CH—X—R-R. The invention relates also to methods of manufacture of such novel AGT substrates, to intermediates useful in the synthesis of such AGT substrates, and to a method of transferring a label from such AGT substrates to O-alkylguanine-DNA alkyltransferase (AGT) fusion proteins comprising proteins of interest.