The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 14, 2010
Filed:
Jun. 03, 2003
Yi LU, Shanghai, CN;
Xin Gao, Shanghai, CN;
Dafu Cui, Shanghai, CN;
Youshang Zhang, Shanghai, CN;
Yangbin Huang, Shanghai, CN;
Jiuru Sun, Shanghai, CN;
Jiang LI, Shanghai, CN;
Jian Fei, Shanghai, CN;
Yi Lu, Shanghai, CN;
Xin Gao, Shanghai, CN;
Dafu Cui, Shanghai, CN;
Youshang Zhang, Shanghai, CN;
Yangbin Huang, Shanghai, CN;
Jiuru Sun, Shanghai, CN;
Jiang Li, Shanghai, CN;
Jian Fei, Shanghai, CN;
Shanghai Centre of Research & Development of New Drugs, Shanghai, CN;
Shanghai Newsummit Biopharma Co., Ltd, Shanghai, CN;
Shanghai Yizhong Biotechnology Co., Ltd, Shanghai, CN;
Abstract
The present invention provides a novel fusion protein suitable for high expression and the production method thereof. The structure of the fusion protein is A-C1-K-(B-C2-K)n-D, wherein A is the upstream peptide; each of C1 and C2 is independently short peptides having 20-40 amino acids in length and containing no Lys in sequence; K is Lys; B is a linker; D is a downstream peptide; n is an integer of 3-30. The fusion protein is expressed with high efficiency and stability in host cells. The purification and enzymatic cleavage technology of the expression product is simple, which is able to produce a short peptide with high efficiency, and has very high value of industrialization.