The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 14, 2010
Filed:
Jan. 23, 2009
Applicants:
LI Chen, Shanghai, CN;
Yun He, Shanghai, CN;
Jason Christopher Wong, Shanghai, CN;
Inventors:
Assignee:
Hoffman-La Roche Inc., Nutley, NJ (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 255/60 (2006.01); C07C 237/20 (2006.01); A61K 31/277 (2006.01); A61K 31/167 (2006.01); A61K 31/54 (2006.01); A61K 31/538 (2006.01); A61K 31/535 (2006.01); A61K 31/495 (2006.01); A61K 31/47 (2006.01); A61K 31/4453 (2006.01); A61K 31/4402 (2006.01); A61K 31/4406 (2006.01); A61K 31/4409 (2006.01); A61K 31/4192 (2006.01); A61K 31/40 (2006.01); A61K 31/381 (2006.01); A61K 31/341 (2006.01); A61K 31/351 (2006.01); C07D 409/12 (2006.01); C07D 333/24 (2006.01); C07D 309/06 (2006.01); C07D 307/54 (2006.01); C07D 295/155 (2006.01); C07D 295/15 (2006.01); C07D 295/185 (2006.01); C07D 279/12 (2006.01); C07D 265/34 (2006.01); C07D 215/14 (2006.01); C07D 213/56 (2006.01); C07D 207/09 (2006.01); C07D 205/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides novel compounds of the general formula (I) and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel compounds and medicaments containing such compounds. The compounds of the present invention show anti-proliferative and differentiation-inducing activity, which results in inhibition of tumor cell proliferation, induction of apoptosis and inhibition of invasion. The invention also covers the use of such compounds for the treatment of diseases such as cancer and for the manufacture of corresponding medicaments.