The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 14, 2010
Filed:
Dec. 07, 2007
Christoph Steeneck, Dossenheim, DE;
Christian Gege, Mauer, DE;
Frank Richter, Handschuheim, DE;
Heiko Kroth, Leimen, DE;
Matthias Hochgurtel, Schriesbeim, DE;
Michael Essors, Schoenau, DE;
Joshua Van Veldhuizen, Brookline, MA (US);
Bert Nolte, Schoenau, DE;
Brian M. Gallagher, Jr., Merrimac, MA (US);
Tim Feuerstein, Neckargemuond, DE;
Matthias Schneider, Dossenheim, DE;
Torsten Arndt, Behsheim, DE;
Hongbo Deng, Southborough, MA (US);
Ralf Biesinger, Ludwigshalen, DE;
Xinyuan Wu, Newton, MA (US);
Harald Bluhm, Dossenheim, DE;
Irving Sucholeiki, Winchester, MA (US);
Arthur G. Taveras, Southborough, MA (US);
Christoph Steeneck, Dossenheim, DE;
Christian Gege, Mauer, DE;
Frank Richter, Handschuheim, DE;
Heiko Kroth, Leimen, DE;
Matthias Hochgurtel, Schriesbeim, DE;
Michael Essors, Schoenau, DE;
Joshua Van Veldhuizen, Brookline, MA (US);
Bert Nolte, Schoenau, DE;
Brian M. Gallagher, Jr., Merrimac, MA (US);
Tim Feuerstein, Neckargemuond, DE;
Matthias Schneider, Dossenheim, DE;
Torsten Arndt, Behsheim, DE;
Hongbo Deng, Southborough, MA (US);
Ralf Biesinger, Ludwigshalen, DE;
Xinyuan Wu, Newton, MA (US);
Harald Bluhm, Dossenheim, DE;
Irving Sucholeiki, Winchester, MA (US);
Arthur G. Taveras, Southborough, MA (US);
Atlantos Pharmaceuticals Holding, Inc., Thousand Oaks, CA (US);
Abstract
The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds having the following formulas: wherein R, R, R, and Rare as defined in the specification. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds amide containing heterobicyclic compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.