The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 07, 2010

Filed:

Nov. 15, 2005
Applicants:

Brian J. Day, Englewood, CO (US);

Remy Kachadourian, Denver, CO (US);

Inventors:

Brian J. Day, Englewood, CO (US);

Remy Kachadourian, Denver, CO (US);

Assignee:

National Jewish Health, Denver, CO (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4164 (2006.01); C07D 233/60 (2006.01);
U.S. Cl.
CPC ...
Abstract

Methods for therapy of cystic fibrosis and other conditions such as cancer are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e. ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis, cancer and/or another condition responsive to stimulation of thiol-containing compound transport.


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