The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 07, 2010

Filed:

Jul. 26, 2005
Applicants:

Choung U. Kim, San Carlos, CA (US);

Johan Neyts, Kessel-Lo, BE;

David A. Oare, Belmont, CA (US);

Gerhard Puerstinger, A-6080 Igls, AT;

Inventors:

Choung U. Kim, San Carlos, CA (US);

Johan Neyts, Kessel-Lo, BE;

David A. Oare, Belmont, CA (US);

Gerhard Puerstinger, A-6080 Igls, AT;

Assignees:

Gilead Sciences, Inc., Foster City, CA (US);

K.U. Leuven Research & Development, Leuven, BE;

Other;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 473/02 (2006.01); A61P 31/14 (2006.01); A61K 31/52 (2006.01); C07D 471/04 (2006.01); A61K 31/4745 (2006.01); C07D 261/08 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one compound having the general formula (A): wherein U is N or C; X is selected from C-Calkylene, Calkenylene or Calkynylene, where each may include one or more intrachain heteroatoms selected from O, S, or NR, provided any such heteroatom is not adjacent to the N in the ring; Ris selected from aryl, aryloxy, arylthio, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl-N(R)—, or heterocycle, where each said substituent is optionally substituted with at least one R, provided that for cycloalkenyl the double bond is not adjacent to a nitrogen; and the other substituents are described in the specification. The invention also relates to processes for the preparation of compounds according to the invention having above mentioned general formula, their pharmaceutically acceptable formulations and their use as a medicine or to treat or prevent viral infections.


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