The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2010
Filed:
Jul. 13, 2006
Bruce L. Geller, Corvallis, OR (US);
Patrick L. Iversen, Corvallis, OR (US);
Lucas D. Tilley, Burlington, VT (US);
Bruce L. Geller, Corvallis, OR (US);
Patrick L. Iversen, Corvallis, OR (US);
Lucas D. Tilley, Burlington, VT (US);
AVI BioPharma Inc., Corvallis, OR (US);
Abstract
An antibacterial antisense conjugate and method of using the same for treating a bacterial infection in a mammalian host are disclosed. The conjugate includes an antisense oligonucleotide conjugated to a carrier peptide that significantly enhances the antibacterial activity of the oligonucleotide. The antisense oligonucleotide contains 10-20 nucleotide bases and has a targeting nucleic acid sequence complementary to a target sequence containing or within 10 bases, in a downstream direction, of the translational start codon of a bacterial mRNA that encodes a bacterial protein essential for bacterial replication, where the compound binds to a target mRNA with a Tof between 50° to 60° C. The carrier peptide is an arginine-rich peptide containing between 6 and 12 amino acids.