The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2010
Filed:
Dec. 02, 2004
Applicants:
Michael Blaber, Tallahassee, FL (US);
Stephen R. Brych, Simi Valley, CA (US);
Inventors:
Michael Blaber, Tallahassee, FL (US);
Stephen R. Brych, Simi Valley, CA (US);
Assignee:
The Florida State University Research Foundation, Inc., Tallahassee, FL (US);
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/06 (2006.01); C12N 15/00 (2006.01); C12N 5/00 (2006.01); A61K 38/18 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
An engineered, purified polypeptide of acidic fibroblast growth factor (FGF-1) is described, the amino acid sequence of which consists essentially of SEQ ID NO: 1. The engineered polypeptide provides 70 times the mitogenic activity of wild type acidic fibroblast growth factor. Other engineered FGFs are also described, having altered properties, including reduced heparin binding affinity and increased mitogenicity as demonstrated with a model mammalian cell line derived from mice, NIH 3T3 fibroblasts.