The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2010
Filed:
Mar. 27, 2007
Emily Sheng-ming Shen, West Chester, PA (US);
Frederick J. Bex, Newtown Square, PA (US);
Yogendra P. Kharode, Media, PA (US);
Vargheese M. Chennathukuzhi, Collegeville, PA (US);
Murty V. Chengalvala, Audubon, PA (US);
Ashok Bapat, Blue Bell, PA (US);
Panayiotis E. Stevis, Glenmoore, PA (US);
Gregory S. Kopf, Villanova, PA (US);
Emily Sheng-Ming Shen, West Chester, PA (US);
Frederick J. Bex, Newtown Square, PA (US);
Yogendra P. Kharode, Media, PA (US);
Vargheese M. Chennathukuzhi, Collegeville, PA (US);
Murty V. Chengalvala, Audubon, PA (US);
Ashok Bapat, Blue Bell, PA (US);
Panayiotis E. Stevis, Glenmoore, PA (US);
Gregory S. Kopf, Villanova, PA (US);
Wyeth LLC, Madison, NJ (US);
Abstract
The invention provides methods for treating or preventing bone degenerative disorders. The disorders treated or prevented include, for example, osteopenia, osteomalacia, osteoporosis, osteomyeloma, osteodystrophy, Paget's disease, osteogenesis imperfecta, and bone degenerative disorders associated with chronic renal disease, hyperparathyroidism, and long-term use of corticosteroids. The disclosed therapeutic methods include administering to a mammal an inhibitor of GDF-9 or BMP-15 in an amount effective to: (1) treat or prevent a bone degenerative disorder; (2) slow bone deterioration; (3) restore lost bone; (4) stimulate new bone formation; and/or (5) maintain bone mass and/or bone quality. The invention also provides methods for administering a GDF-9 agonist or a BMP-15 agonist to treat a bone disorder characterized by increased bone density or mass.