The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2010
Filed:
Jun. 14, 2004
Claudia Woppmann, Gesees, DE;
Hans-peter Vornlocher, Bayreuth, DE;
Philipp Hadwiger, Altenkunstadt, DE;
Matthias John, Hallstadt, DE;
Stefan Limmer, Kulmbach, DE;
Claudia Woppmann, Gesees, DE;
Hans-Peter Vornlocher, Bayreuth, DE;
Philipp Hadwiger, Altenkunstadt, DE;
Matthias John, Hallstadt, DE;
Stefan Limmer, Kulmbach, DE;
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The present invention relates to a method for the targeted selection of a double-stranded ribonucleic acid (dsRNA) consisting of two single strands that exhibits increased effectiveness in inhibiting the expression of a target gene by means of RNA interference, wherein at least end of the dsRNA comprises a nucleotide overhang of 1 to 4 unpaired nucleotides in length; wherein the unpaired nucleotide adjacent to the terminal nucleotide pair comprises a purine base; and wherein the terminal nucleotide pair on both ends of the dsRNA is a G-C pair, or at least two of the last four consecutive terminal nucleotide pairs are G-C pairs.