The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2010
Filed:
Sep. 02, 2004
Gregory DE Crescenzo, Montreal, CA;
Maureen D. O'conner, Beaconsfield, CA;
Beatrice Paul-roc, Montreal, CA;
John Zwaagstra, Laval, CA;
Myriam Banville, Laval, CA;
Maria Jaramillo, Beaconsfield, CA;
Gregory De Crescenzo, Montreal, CA;
Maureen D. O'Conner, Beaconsfield, CA;
Beatrice Paul-Roc, Montreal, CA;
John Zwaagstra, Laval, CA;
Myriam Banville, Laval, CA;
Maria Jaramillo, Beaconsfield, CA;
National Research Council of Canada, Ottawa, ON, CA;
Abstract
Fusion proteins and coiled-coil induced dimers prepared from both the ectodomains and the kinase domains are disclosed. The receptor domains when presented in the form of a homodimer or heterodimer by virtue of the coiled-coil tag have enhanced ligand binding activity or enhanced kinase activity. The kinetics of binding and the antagonistic potencies of the ectodomain dimers, and their use to alter or inhibit signaling is described. Application of the ectodomain and kinase domain dimers in assays for selecting compounds capable of inhibiting ligand binding and kinase activity, respectively, is described.