The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2010
Filed:
Oct. 12, 2006
Siripragada Mahender Rao, Chennai, IN;
Akella Satya Surya Visweswara Srinvas, Chennai, IN;
Shikha Rani, Chennai, IN;
Gaddam OM Reddy, Chennai, IN;
Sriram Rajagopal, Chennai, IN;
Uma Ramachandran, Chennai, IN;
Duddu Savaraiah Sharada, Chennai, IN;
Rajagopalan Nirmala, Chennai, IN;
Velaiah Sivasudar, Chennai, IN;
Lakshmanan Manikandan, Chennai, IN;
Ramachandran Balaji, Chennai, IN;
Siripragada Mahender Rao, Chennai, IN;
Akella Satya Surya Visweswara Srinvas, Chennai, IN;
Shikha Rani, Chennai, IN;
Gaddam Om Reddy, Chennai, IN;
Sriram Rajagopal, Chennai, IN;
Uma Ramachandran, Chennai, IN;
Duddu Savaraiah Sharada, Chennai, IN;
Rajagopalan Nirmala, Chennai, IN;
Velaiah Sivasudar, Chennai, IN;
Lakshmanan Manikandan, Chennai, IN;
Ramachandran Balaji, Chennai, IN;
Orchid Research Laboratories, Ltd., Chennai, IN;
Abstract
The present invention relates to novel heterocyclic compounds of the general formula (I), as IL-6 inhibitors, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions, their metabolites and prodrugs thereof. The present invention more particularly provides novel heterocyclic compounds of the general formula (I). Also included is a method for treatment of cancer, cancer cachexia and inflammatory diseases including immunological diseases, particularly those mediated by cytokines such as IL-6, through pSTAT3 inhibition, in a mammal comprising administering an effective amount of a compound of formula (I) as described above