The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2010
Filed:
Apr. 29, 2004
Jürg Zumbrunn, Känerkinden, CH;
Steven J. Demarco, Diegten, CH;
Sergio Lociuro, Reinach, CH;
Jan Wim Vrijbloed, Möhlin, CH;
Frank Gombert, Huttingen, DE;
Reshmi Mukherjee, Newton, MA (US);
Kerstin Moehle, Wettswil, CH;
Daniel Obrecht, Bättwil, CH;
John Anthony Robinson, Wermatswil, CH;
Heiko Henze, Zürich, CH;
Barbara Romagnoli, St. Louis, FR;
Christian Ludin, Oberwil, CH;
Jürg Zumbrunn, Känerkinden, CH;
Steven J. Demarco, Diegten, CH;
Sergio Lociuro, Reinach, CH;
Jan Wim Vrijbloed, Möhlin, CH;
Frank Gombert, Huttingen, DE;
Reshmi Mukherjee, Newton, MA (US);
Kerstin Moehle, Wettswil, CH;
Daniel Obrecht, Bättwil, CH;
John Anthony Robinson, Wermatswil, CH;
Heiko Henze, Zürich, CH;
Barbara Romagnoli, St. Louis, FR;
Christian Ludin, Oberwil, CH;
Polyphor Ltd., Allschwil, CH;
Universität Zürich, Zürich, CH;
Abstract
Template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12, 14 or 18 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, NMeGly, Pro or Pip, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid—and solution phase synthetic strategy.