The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2010
Filed:
May. 04, 2005
Rainer Stürmer, Rödersheim-Gronau, DE;
Maria Keβeler, Mannheim, DE;
Bernhard Haur, Fuβgönheim, DE;
Thomas Friedrich, Darmstadt, DE;
Michael Breuer, Limburgerhof, DE;
Hartwig Schröder, Nuβloch, DE;
Rainer Stürmer, Rödersheim-Gronau, DE;
Maria Keβeler, Mannheim, DE;
Bernhard Haur, Fuβgönheim, DE;
Thomas Friedrich, Darmstadt, DE;
Michael Breuer, Limburgerhof, DE;
Hartwig Schröder, Nuβloch, DE;
BASF SE, Ludwigshafen, DE;
Abstract
The invention relates to a method for producing the optically active alkanols of formula (I), wherein n is an integer of from 0 to 5; Cyc represents an optionally substituted, mononuclear or polynuclear, saturated or unsaturated, carbocylic or heterocyclic ring, and Rrepresents halogen, SH, OH, NO, NRRor NRRRX, wherein R, Rand Rindependently represent H or a lower alkyl or lower alkoxy group and Xrepresents a counterion. According to the invention, an enzyme (E) selected from the groups of dehydrogenases, aldehyde reductases and carbonyl reductases is incubated in a medium containing the alkanone of formula (II), wherein n, Cyc and Rare defined as above, in the presence of reduction equivalents. The compound of formula (II) is enzymatically reduced to the compound of formula (I) and the reduction equivalents consumed during reaction are regenerated by reacting a sacrificial alcohol to the corresponding sacrificial ketone using enzyme (E) and at least partially removing the sacrificial ketone from the reaction medium, and then isolating the product (I) so produced.