The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2010
Filed:
May. 01, 2007
Peter L. Sazani, Chapel Hill, NC (US);
Maria Graziewicz, Chapel Hill, NC (US);
Ryszard Kole, Chapel Hill, NC (US);
Henrik Ørum, Vaerlose, DK;
Peter L. Sazani, Chapel Hill, NC (US);
Maria Graziewicz, Chapel Hill, NC (US);
Ryszard Kole, Chapel Hill, NC (US);
Henrik Ørum, Vaerlose, DK;
Ercole Biotech, Inc., Research Triangle Park, NC (US);
University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Santaris Pharma A/S, Horsholm, DK;
Abstract
The present invention relates to tumor necrosis factor (TNF) antagonists and corresponding nucleic acids derived from tumor necrosis factor receptors (TNFRs) and their use in the treatment of inflammatory diseases. These proteins are soluble secreted decoy receptors that bind to TNF and prevent TNF from signaling to cells. In particular, the proteins are mammalian TNFRs that lack exon 7 and which can bind TNF and can act as a TNF antagonist.