The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2010
Filed:
May. 20, 2004
Felicity Meredith Dunlop, Regent, AU;
Manuel Baca, Viewbank, AU;
Andrew Donald Nash, Kew, AU;
Louis Jerry Fabri, Diamond Creek, AU;
Douglas James Hilton, Warrandyte, AU;
Nicos a Nicola, Mont Albert, AU;
Felicity Meredith Dunlop, Regent, AU;
Manuel Baca, Viewbank, AU;
Andrew Donald Nash, Kew, AU;
Louis Jerry Fabri, Diamond Creek, AU;
Douglas James Hilton, Warrandyte, AU;
Nicos A Nicola, Mont Albert, AU;
Zenyth Operations Pty Ltd., Richmond, Victoria, AU;
Abstract
The present invention relates generally to antibodies that bind to the Interleukin-13 receptor α1 chain (IL-13Rα1) and antagonize IL-13 receptor-mediated signaling by IL-13 and/or IL-4. More particularly, the present invention provides humanized or human antibodies to mammalian and in particular IL-13Rα1. These antibodies have uses in the treatment or prevention of IL-13- and/or IL-4-mediated diseases or conditions. The present invention further contemplates a method of modulating IL-13- and/or IL-4-mediated diseases or conditions by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies or other agents which modulate IL-13 and/or IL-4 signaling through an IL-13 receptor complex. Accordingly, a method of screening for modulators of IL-13Rα1/ligand interaction is also provided.