The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2010
Filed:
May. 10, 2005
Michel Hocquaux, Paris, FR;
Anne-marie Pinel, Toulouse, FR;
Jean Martinez, Caux, FR;
Gilles Subra, Juvignac, FR;
Michel Hocquaux, Paris, FR;
Anne-Marie Pinel, Toulouse, FR;
Jean Martinez, Caux, FR;
Gilles Subra, Juvignac, FR;
Institut Europeen de Biologie Cellulaiare, Ramonville St. Agne, FR;
Centre National de la Recherche Scientifique (CNRS), Paris, FR;
Universite de Montpellier I, Montpellier, FR;
Universite de Montpellier II, Montpellier, FR;
Abstract
The invention relates to a peptide of formula W-DPhe-Arg-Z (I) and to a conjugate thereof of a formula A-W-DPhe-Arg-Z (II), wherein A is a radical corresponding to a monocarboxylic acid of general formula HOOC—R (III), wherein R is an linear or branched possibly substituted by a hydroxy group aliphatic C-Cradical which can comprise one or several unsaturations, preferably from 1 to 6 unsaturations, a lipoic acid or the reduced form thereof, a dihydrolipoic acid, N-lipoyl-lysine or a phenylbutyric acid, W is His, Ala-His, Ala-Ala-His, Nle-Ala-His, DTrp-Ala-His, Nle-Trp-His, Lys, Ala-Lys, Nle-Ala-Lys, Orn, Ala-Orn, Nle-Ala-Orn, Ala, Nle-Ala-Ala, Arg, Ala-Arg. Nle-Ala-Arg, Nle-Ala-DTrp or a bond in case of compounds of formula (II), Z is NH, OH and OR, wherein R is a linear or branched aliphatic C-Cradical, TrpNH, NapNH, TpiNH, TicNH, AlaNH2TrpOH, NapOH, TpiOH, TicOH, AlaOH, PheNH, or PheOH, exempting a peptidic conjugate for which A is a radical corresponding to an acetic acid, W is Nle-Ala-His and Z is TrpNHin the form of enantiomers or diastereoisomer and the mixtures thereof including racemic mixtures. The use of the inventive compounds for cosmetically fighting against canities is also disclosed.