The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 24, 2010

Filed:

Dec. 29, 2006
Applicants:

Amjad Ali, Freehold, NJ (US);

Zhijian LU, Clinton, NJ (US);

Peter J. Sinclair, Scotch Plains, NJ (US);

Gayle E. Taylor, Jersey City, NJ (US);

Christopher F. Thompson, Clark, NJ (US);

Cameron J. Smith, Lawrenceville, NJ (US);

Adrian A. Dowst, Hoboken, NJ (US);

Yi-heng Chen, Whippany, NJ (US);

Inventors:

Amjad Ali, Freehold, NJ (US);

Zhijian Lu, Clinton, NJ (US);

Peter J. Sinclair, Scotch Plains, NJ (US);

Gayle E. Taylor, Jersey City, NJ (US);

Christopher F. Thompson, Clark, NJ (US);

Cameron J. Smith, Lawrenceville, NJ (US);

Adrian A. Dowst, Hoboken, NJ (US);

Yi-Heng Chen, Whippany, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/422 (2006.01); A61K 31/5377 (2006.01); A61K 31/541 (2006.01); A61K 31/496 (2006.01); A61K 31/443 (2006.01); A61K 31/4525 (2006.01); A61K 31/55 (2006.01); C07D 403/02 (2006.01); C07D 413/02 (2006.01); C07D 417/02 (2006.01); C07D 401/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), B or Ris a phenyl group which has an ortho amine or aminomethyl substituent which is further substituted, and the other of B or Ris also a cyclic group.


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