The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2010
Filed:
Oct. 08, 2003
Applicants:
William Alexander Denny, Auckland, NZ;
Graham J. Atwell, Auckland, NZ;
Shangjin Yang, Auckland, NZ;
William Robert Wilson, Waiuku, NZ;
Adam Vorn Patterson, Auckland, NZ;
Inventors:
William Alexander Denny, Auckland, NZ;
Graham J. Atwell, Auckland, NZ;
Shangjin Yang, Auckland, NZ;
William Robert Wilson, Waiuku, NZ;
Adam Vorn Patterson, Auckland, NZ;
Assignee:
Auckland Uniservices Limited, Auckland, NZ;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/135 (2006.01); C07C 237/28 (2006.01);
U.S. Cl.
CPC ...
Abstract
Nitroaniline-based unsymmetrical mustards of the general formula (I) are provided, together with methods of preparation and methods for their use as prodrugs for gene-dependent enzyme prodrug therapy (GDEPT) and cell ablation therapy in conjunction with nitroreductase enzymes as hypoxia selective cytotoxins and as anticancer agents.