The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2010
Filed:
Sep. 14, 2005
Takeshi Murakami, Chuo-ku, JP;
Tomoaki Kawano, Chuo-ku, JP;
Ryota Shiraki, Chuo-ku, JP;
Hirofumi Ishii, Chuo-ku, JP;
Seiji Yoshimura, Chuo-ku, JP;
Takehiko Ohkawa, Chuo-ku, JP;
Mitsuru Hosaka, Chuo-ku, JP;
Hiroki Fukudome, Chuo-ku, JP;
Yutaka Inoki, Chuo-ku, JP;
Takeshi Murakami, Chuo-ku, JP;
Tomoaki Kawano, Chuo-ku, JP;
Ryota Shiraki, Chuo-ku, JP;
Hirofumi Ishii, Chuo-ku, JP;
Seiji Yoshimura, Chuo-ku, JP;
Takehiko Ohkawa, Chuo-ku, JP;
Mitsuru Hosaka, Chuo-ku, JP;
Hiroki Fukudome, Chuo-ku, JP;
Yutaka Inoki, Chuo-ku, JP;
Astellas Pharma Inc., Tokyo, JP;
Abstract
There is provided a compound which can be used for therapy of diseases in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) participates, in particular diabetes, insulin resistance. It has been found that a triazole derivative wherein the triazole ring is substituted with a trisubstituted methyl group in the 2-position or a pharmaceutically acceptable salt thereof has a strong 11β-HSD1 inhibitory activity. Moreover, the triazole derivative of the invention exhibits an excellent blood-glucose level-lowering action and hence can be used for therapy of diabetes, insulin resistance.