The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2010
Filed:
Jun. 29, 2005
John Laird Buchanan, Newton, MA (US);
William H. Buckner, Arlington, MA (US);
Simon A. Burkitt, Ravenshead, GB;
Erin F. Dimauro, Cambridge, MA (US);
Christopher N. Farthing, London, GB;
Alexander D. Frenkel, Buxton, GB;
Martin J. Harrison, Stockport, GB;
Frank Kayser, San Francisco, CA (US);
Jinqian Liu, Palo Alto, CA (US);
Sarah E. Lively, San Carlos, CA (US);
Teresa L. Marshall, Stow, MA (US);
David C. Mcgowan, Woluwe St. Pierre, BE;
Rajiv Sharma, Fremont, CA (US);
Stephen J. Shuttleworth, Bourne End, GB;
Xiaotian Zhu, Newton, MA (US);
John Laird Buchanan, Newton, MA (US);
William H. Buckner, Arlington, MA (US);
Simon A. Burkitt, Ravenshead, GB;
Erin F. DiMauro, Cambridge, MA (US);
Christopher N. Farthing, London, GB;
Alexander D. Frenkel, Buxton, GB;
Martin J. Harrison, Stockport, GB;
Frank Kayser, San Francisco, CA (US);
Jinqian Liu, Palo Alto, CA (US);
Sarah E. Lively, San Carlos, CA (US);
Teresa L. Marshall, Stow, MA (US);
David C. McGowan, Woluwe St. Pierre, BE;
Rajiv Sharma, Fremont, CA (US);
Stephen J. Shuttleworth, Bourne End, GB;
Xiaotian Zhu, Newton, MA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The present invention relates to furanopyrimidine compounds having the general Formula I: and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of treating various diseases and conditions in a mammal, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma and thymoma, comprising administering to the mammal a therapeutically effective amount of a compound of Formula I. The invention also relates to methods of manufacturing medicaments, which comprise one or more compounds of Formula I.