The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2010
Filed:
Apr. 03, 2008
Victor Cee, Thousand Oaks, CA (US);
Holly Deak, Brookline, MA (US);
Bingfan Du, Cambridge, MA (US);
Stephanie Geuns-meyer, Medford, MA (US);
Brian L. Hodous, Cambridge, MA (US);
Zihao Hua, Tewksbury, MA (US);
Matthew Martin, Cambridge, MA (US);
Isaac Marx, Somerville, MA (US);
Hanh Nho Nguyen, Arlington, MA (US);
Philip Olivieri, Charlestown, MA (US);
Kathleen Panter, Cambridge, MA (US);
Karina Romero, Cambridge, MA (US);
Laurie Schenkel, Boston, MA (US);
Ryan White, Somerville, MA (US);
Victor Cee, Thousand Oaks, CA (US);
Holly Deak, Brookline, MA (US);
Bingfan Du, Cambridge, MA (US);
Stephanie Geuns-Meyer, Medford, MA (US);
Brian L. Hodous, Cambridge, MA (US);
Zihao Hua, Tewksbury, MA (US);
Matthew Martin, Cambridge, MA (US);
Isaac Marx, Somerville, MA (US);
Hanh Nho Nguyen, Arlington, MA (US);
Philip Olivieri, Charlestown, MA (US);
Kathleen Panter, Cambridge, MA (US);
Karina Romero, Cambridge, MA (US);
Laurie Schenkel, Boston, MA (US);
Ryan White, Somerville, MA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The present invention relates to chemical compounds having a general formula I wherein A, D', L, L, R, Rand n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.