The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2010
Filed:
Sep. 20, 2004
Applicants:
Ben G. Szaro, Albany, NY (US);
James Castracane, Albany, NY (US);
Xiaojun Feng, Albany, NY (US);
Inventors:
Assignee:
The Research Foundation of State University of New York, Albany, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
C40B 30/06 (2006.01); C40B 40/02 (2006.01); C12N 5/00 (2006.01); C12N 5/02 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention relates to a biosensor comprising living cells that express a chemosensor, or receptor, on their surface. When grown on a microarray comprising electrodes, the cells can be induced, by binding of a ligand to the receptor, to secrete a molecule. This secretion event is detected with millisecond temporal resolution via electrochemical oxidation of the secreted molecule on the electrode which is voltage-clamped slightly above its redox potential. The current so generated is indicative of the amount of the ligand bound to the receptor.