The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2010
Filed:
Jul. 08, 2005
Gunther Hartmann, Munich, DE;
Robert L. Bratzler, Concord, MA (US);
Arthur M. Krieg, Wellesley, MA (US);
Gunther Hartmann, Munich, DE;
Robert L. Bratzler, Concord, MA (US);
Arthur M. Krieg, Wellesley, MA (US);
University of Iowa Research Foundation, Iowa City, IA (US);
Coley Pharmaceutical GmbH, Dusseldorf, DE;
Coley Pharmaceutical Group, Inc., New York, NY (US);
Abstract
Methods and compositions are provided for extending the clinical utility of IFN-α in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-α treatment and reduce IFN-α treatment-related side effects. In addition, methods are provided for supporting the survival and for activating natural interferon producing cells (IPCs) in vitro without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.