The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2010
Filed:
May. 25, 2007
Eleanor Fish, Toronto, CA;
Carole Galligan, Scarborough, CA;
Kathy Siminovitch, Toronto, CA;
Omar Perez, San Francisco, CA (US);
Edward Keystone, Toronto, CA;
Vivian Bykerk, Toronto, CA;
Eleanor Fish, Toronto, CA;
Carole Galligan, Scarborough, CA;
Kathy Siminovitch, Toronto, CA;
Omar Perez, San Francisco, CA (US);
Edward Keystone, Toronto, CA;
Vivian Bykerk, Toronto, CA;
University Health Network, Ontario, CA;
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Abstract
The invention provides a novel cell that is a precursor of a fibroblast-like synovial cell. The novel cell is a circulating synovial tissue cell that stains positive for collagen, CD34, CD45, prolyl 4-hydroxylase and CD14. The invention also relates to methods of diagnosing or monitoring rheumatoid arthritis and/or osteoarthritis using gene expression profiles, protein expression profiles, and/or protein phosphorylation profiles of different cell types, including the novel precursor, CD3+ cells, synovial tissue fibroblast-like synovial cells and fibrocytes. The invention also includes methods to identify substances to treat or prevent rheumatoid arthritis and/or osteoarthritis.