The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 10, 2010
Filed:
Apr. 01, 2008
Joerg Bewersdorf, Bar Harbor, ME (US);
Manuel F. Juette, Rosrath, DE;
Travis Gould, Old Town, ME (US);
Sam T. Hess, Stillwater, ME (US);
Joerg Bewersdorf, Bar Harbor, ME (US);
Manuel F. Juette, Rosrath, DE;
Travis Gould, Old Town, ME (US);
Sam T. Hess, Stillwater, ME (US);
The Jackson Laboratory, Bar Harbor, ME (US);
University of Maine, Orono, ME (US);
Abstract
A microscopy system is configured for creating 3D images from individually localized probe molecules. The microscopy system includes a sample stage, an activation light source, a readout light source, a beam splitting device, at least one camera, and a controller. The activation light source activates probes of at least one probe subset of photo-sensitive luminescent probes, and the readout light source causes luminescence light from the activated probes. The beam splitting device splits the luminescence light into at least two paths to create at least two detection planes that correspond to the same or different number of object planes of the sample. The camera detects simultaneously the at least two detection planes, the number of object planes being represented in the camera by the same number of recorded regions of interest. The controller is programmable to combine a signal from the regions of interest into a 3D data.