The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 10, 2010
Filed:
Sep. 24, 2008
David S. Garvey, Dover, MA (US);
Ricky D. Gaston, Malden, MA (US);
L. Gordon Letts, Dover, MA (US);
Inigo Saenz DE Tejada, Madrid, ES;
Sang William Tam, Dover, MA (US);
Manuel Worcel, Boston, MA (US);
David S. Garvey, Dover, MA (US);
Ricky D. Gaston, Malden, MA (US);
L. Gordon Letts, Dover, MA (US);
Inigo Saenz de Tejada, Madrid, ES;
Sang William Tam, Dover, MA (US);
Manuel Worcel, Boston, MA (US);
NitroMed, Inc., Charlotte, NC (US);
Abstract
The invention describes novel nitrosated and/or nitrosylated prostaglandins, and novel compositions comprising at least one nitrosated and/or nitrosylated prostaglandin, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and/or at least one vasoactive agent. The invention also provides novel compositions comprising at least one prostaglandin and at least one S-nitrosothiol compound, and, optionally, at least one vasoactive agent. The prostaglandin is preferably a prostaglandin Ecompound, more preferably alprostadil, and the S-nitrosothiol compound is preferably S-nitrosoglutathione. The invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing cerebrovascular disorders, cardiovascular disorders, benign prostatic hyperplasia (BPH), glaucoma, peptic ulcers or for inducing abortions.