The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 10, 2010
Filed:
Dec. 13, 2004
Julia Adam-worrall, New House, GB;
Julia Adam-Worrall, New House, GB;
N.V. Organon, Oss, NL;
Abstract
The invention relates to tricyclic 1-[(indol-3-yl)carbonyl]piperazine derivative having the general Formula (I) wherein X is CH, O or S; R represents 1-3 substituents independently selected from H, (C)alkyl, (C)alkyloxy and halogen; Ris (C)cycloalkyl; Ris H or (C)alkyl; R, R', R′ R′, R, R′ and R′ are independently hydrogen or (C)-alkyl, optionally substituted with (C)alkyloxy, OH or halogen; Ris hydrogen or (C)alkyl, optionally substituted with (C)alkyloxy, OH or halogen; or Rforms together with Ra 4-7 membered saturated heterocyclic ring, optionally containing a further heteroatom selected from O and S; Rforms together with Ra 4-7 membered saturated heterocyclic ring, optionally containing a further heteroatom selected from O and S; or Ris H, (C)alkyl or (C)cycloalkyl, the alkyl groups being optionally substituted with OH, halogen or (C)alkyloxy; or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said tricyclic 1-[(indol-3-yl)carbonyl]piperazine derivatives, and to the use of these derivatives in the treatment of pain, such as peri-operative pain, chronic pain neuropathic pain, cancer pain, and pain and spasticity associated with multiple sclerosis.