The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 10, 2010
Filed:
Feb. 05, 2010
Richard E. Herman, Redmond, WA (US);
Ekaterina G. Makienko, Lynnwood, WA (US);
Douglas L. Badders, Seattle, WA (US);
Mark Fuller, Roslyn, WA (US);
Richard E. Herman, Redmond, WA (US);
Ekaterina G. Makienko, Lynnwood, WA (US);
Douglas L. Badders, Seattle, WA (US);
Mark Fuller, Roslyn, WA (US);
MDRNA, Inc., Bothell, WA (US);
Abstract
This disclosure provides the construction, expression, and selection of the mutated genes that encode novel Trp cage polypeptides with desirable binding properties, as well as the novel Trp cage polypeptides themselves. The substances or targets bound by these novel Trp cage polypeptides may be but need not be proteins or polypeptides. Targets may include other biological or synthetic macromolecules as well as other organic and inorganic substances. Further, targets may also include a single or multiple cell or tissue types. The present invention achieves genetic variants of Trp cage-encoding nucleic acids through controlled random mutagenesis of the nucleic acids yielding a mixture of Trp cage polypeptides that are capable of binding targets.