The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 10, 2010
Filed:
May. 17, 2005
Yury Vladimirovich Matsuka, New Windsor, NY (US);
Steven Morris Baker, Highland Mills, NY (US);
Elizabeth Teremy Anderson, Lansdale, PA (US);
Yury Vladimirovich Matsuka, New Windsor, NY (US);
Steven Morris Baker, Highland Mills, NY (US);
Elizabeth Teremy Anderson, Lansdale, PA (US);
Wyeth LLC, Madison, NJ (US);
Abstract
An isolated, altered fibronectin-binding protein (Fnb) ofhaving at least one mutation in an amino acid selected from residues corresponding to Gln103, Gln105, Lys157, Lys503, Lys620, Lys702, Lys762, Gln783 and Gln830 of FnbA ofstrain ATCC49525 is described. Replacement of these reactive residues within the fibronectin-binding protein renders this protein less capable than wild-type Fnb of covalently cross-linking with fibronectin and fibrin. The altered fibronectin-binding protein effectively interferes with adhesion ofto fibronectin and fibrin, and therefore, an immunogenic composition comprising such altered Fnb exhibits improved immunogenic properties and is safer to use.