The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 10, 2010
Filed:
Jun. 23, 2008
Francesco Tisato, Padua, IT;
Cristina Bolzati, Jolanda di Savoja, IT;
Marina Porchia, Padua, IT;
Fiorenzo Refosco, Valdagno, IT;
Francesco Tisato, Padua, IT;
Cristina Bolzati, Jolanda di Savoja, IT;
Marina Porchia, Padua, IT;
Fiorenzo Refosco, Valdagno, IT;
Bracco Imaging S.p.A., Milan, IT;
Abstract
The present invention provides radioactive metal heterocomplexes of formula (I): [(Me=N—R)LL]+Zwherein Me, R, LLand Zhave the meanings indicated in the description. The complexes include a trivalent radioactive metal-imido group, typically a technetium-or rhenium-imido group, strongly stabilized by the presence of an ancillary tridentate hetero-diphosphine ligand L, which allows the formation of substitution-inert [(Me=N—R)L] moieties. Such moieties are fixed in an intermediate [(Me=N—R)YL)]+ compound which contains two labile, cispositioned, Y ligands, where Y is preferably an halide group. The latter are easily replaced by a bidentate ligand Lto give the final [(Me=N—R)LL]+ Zheterocomplexes. The complexes of the invention are useful for the preparation of radiopharmaceuticals: in fact, a bioactive fragment which confers biological target-seeking properties can be introduced either on the Lframework or the imido R group.