The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2010
Filed:
Dec. 20, 2004
Jae Suk Koh, Daejeon, KR;
Chun Young Kim, Daejeon, KR;
Byoung IN Lee, Daejeon, KR;
Sang Soo Lee, Daejeon, KR;
Seong Jun Lee, Daejeon, KR;
Jong Ho Lim, Daejeon, KR;
Seon Yeong Jeon, Daejeon, KR;
Jun Bae Hong, Daejeon, KR;
Jae Suk Koh, Daejeon, KR;
Chun Young Kim, Daejeon, KR;
Byoung In Lee, Daejeon, KR;
Sang Soo Lee, Daejeon, KR;
Seong Jun Lee, Daejeon, KR;
Jong Ho Lim, Daejeon, KR;
Seon Yeong Jeon, Daejeon, KR;
Jun Bae Hong, Daejeon, KR;
SK Holdings Co., Ltd., Seoul, KR;
Abstract
Disclosed herein is a method of producing an optically active thiophene-based compound using a simulated moving bed adsorption separation process, and more specifically, a method of continuously separating a racemic thiophene-based compound into its optically active thiophene-based compounds having high purity, through optical resolution using the simulated moving bed process. According to the method of the current invention, a racemic mixture of a thiophene-based compound can be continuously separated into its optically active thiophene-based compounds having high purity, which is an intermediate of optically active dorzolamide acting as a topical therapeutic agent for glaucoma, using a simulated moving bed adsorption separation technique, thereby increasing industrial usability.