The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2010
Filed:
Apr. 21, 2006
Michael Edward Cooper, Cardiff, GB;
Nicholas John Gardner, Cardiff, GB;
Peter Gordon Laughton, Cardiff, GB;
Michael Edward Cooper, Cardiff, GB;
Nicholas John Gardner, Cardiff, GB;
Peter Gordon Laughton, Cardiff, GB;
GE Healthcare UK Limited, Amersham, GB;
Abstract
Disclosed are cyanine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which at least one of groups R, R, R, R, R, R, R, R, R, RR, R, Rand Ris -L-M or -L-P, where L is a linking group, M is a target bonding group and P is a conjugated component, and at least one of groups R, R, R, R, R, R, Rand Rcomprises fluorine. The use of cyanine dyes substituted by fluorine and having additional substitution with three or more sulphonic acid groups for labelling biological target molecules results in a labelled product in which there is reduced dye-dye aggregation and improved photostability, compared with cyanine dyes having no such substitutions. The dyes of the present invention are particularly useful in assays involving fluorescence detection where continual or repeated excitation is a requirement, for example in kinetic studies, or in microarray analyses where microarray slides may need to be reanalysed over a period of days.