The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2010
Filed:
Sep. 23, 2008
Applicants:
Dan Maarten Berger, New City, NY (US);
Dennis William Powell, Cortlandt Manor, NY (US);
Biqi Wu, Nanuet, NY (US);
Inventors:
Dan Maarten Berger, New City, NY (US);
Dennis William Powell, Cortlandt Manor, NY (US);
Biqi Wu, Nanuet, NY (US);
Assignee:
Wyeth, Madison, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/445 (2006.01); A61K 31/496 (2006.01); A61K 31/501 (2006.01); C07D 211/68 (2006.01); C07D 241/02 (2006.01);
U.S. Cl.
CPC ...
Abstract
This invention provides a compound of Formula 1 where Ar, X, R, R, R, and Rare defined herein, or a pharmaceutically acceptable salt thereof useful in the prevention or inhibition of diseases associated with the Ras/Raf/MEK signaling cascade in a mammal, such as neoplasms, strokes, osteoporosis, cancer, rheumatoid arthritis, inflammatory disease, polycystic kidney disease, and colonic polyps, and methods of making the compounds of formula 1 and intermediates.