The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2010
Filed:
Jan. 27, 2006
Jason C. Murphy, Ambler, PA (US);
David B. Boyd, Quakertown, PA (US);
Adam Joel Kristopeit, North Wales, PA (US);
Russel Jackson Lander, Lansdale, PA (US);
Michael Albert Winters, Doylestown, PA (US);
Jason C. Murphy, Ambler, PA (US);
David B. Boyd, Quakertown, PA (US);
Adam Joel Kristopeit, North Wales, PA (US);
Russel Jackson Lander, Lansdale, PA (US);
Michael Albert Winters, Doylestown, PA (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
Methods of isolating clinical-grade plasmid DNA from manufacturing processes, including large-scale fermentation regimes, are disclosed which encompass alternatives to two core unit operations common to plasmid DNA purification processes. The novel upstream and downstream purification processes disclosed herein provide for reduced production costs and increase process robustness. Either or both of the purification processes disclosed herein may be used in combination with additional purification steps known in the art that are associated with DNA plasmid purification technology.