The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2010
Filed:
Feb. 09, 2001
Tariq Ghayer, Holliston, MA (US);
Richard W. Dixon, Jefferson, MA (US);
Michael Roguska, Ashland, MA (US);
Michael White, Framingham, MA (US);
Boris Labkovsky, Marlborough, MA (US);
Jochen Salfeld, North Grafton, MA (US);
Alexander Robert Duncan, Little Shelford, GB;
Simon Mark Brocklehurst, Fulbourn, GB;
John Mankovich, Andover, MA (US);
Celia Patricia Shorrock, Cambridge, GB;
Julia Elizabeth Thompson, Whittlesford, GB;
Simon Nicholas Lennard, Linton, GB;
Tariq Ghayer, Holliston, MA (US);
Richard W. Dixon, Jefferson, MA (US);
Michael Roguska, Ashland, MA (US);
Michael White, Framingham, MA (US);
Boris Labkovsky, Marlborough, MA (US);
Jochen Salfeld, North Grafton, MA (US);
Alexander Robert Duncan, Little Shelford, GB;
Simon Mark Brocklehurst, Fulbourn, GB;
John Mankovich, Andover, MA (US);
Celia Patricia Shorrock, Cambridge, GB;
Julia Elizabeth Thompson, Whittlesford, GB;
Simon Nicholas Lennard, Linton, GB;
Abbott Laboratories, Abbott Park, IL (US);
Abstract
Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.