The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2010
Filed:
Mar. 18, 2002
Drew M. Pardoll, Brookeville, MD (US);
Linzhao Cheng, Columbia, MD (US);
Yan Cui, New Orleans, LA (US);
Curt I Civin, Towson, MD (US);
Katherine Whartenby, Baltimore, MD (US);
Drew M. Pardoll, Brookeville, MD (US);
Linzhao Cheng, Columbia, MD (US);
Yan Cui, New Orleans, LA (US);
Curt I Civin, Towson, MD (US);
Katherine Whartenby, Baltimore, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
The invention provides methods and compositions for the modulation of systemic immune responses by transplantation of hematopoietic stem cells transduced with genes encoding antigens and antigen presenting cell regulatory molecules. The invention includes bi-cistronic lentiviral expression vectors adapted for antigen expression in antigen presenting cells for use in DNA vaccines directed against pathogens and tumor antigens as well as for the treatment of autoimmune disease and for the establishment of antigen tolerance.