Ecteinascidin analogs for use as antitumour agents

Abstract

Derivatives of ecteinascidin 736 of general formula (I) wherein the groups R, R, R, Rand Rare each independently selected from the group consisting of H, OH, OR', SH, SR′, SOR′, SOR′, C(═O)R′, C(═O)OR′, NO, NH, NHR′, N(R′), NHC(O)R′, CN, halogen, ═O, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic; wherein X is independently selected of OR′, CN, (═O), or H; wherein each of the R′ groups is independently selected from the group consisting of H, OH, NO, NH, SH, CN, halogen, ═O, C(═O)H, C(═O)CH, COH, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted or unsubstituted aryl; wherein m is 0, 1 or 2; and wherein n is 0, 1, 2, 3, or 4, and their use as antitumoral agent.