The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 20, 2010

Filed:

Jan. 30, 2006
Applicants:

Min GE, Edison, NJ (US);

Lihu Yang, Edison, NJ (US);

Changyou Zhou, Princeton, NJ (US);

Songnian Lin, Monroe, NJ (US);

Haifeng Tang, Metuchen, NJ (US);

Eric Dean Cline, Princeton, NJ (US);

Sunita Malkani, Lincoln Park, NJ (US);

Inventors:

Min Ge, Edison, NJ (US);

Lihu Yang, Edison, NJ (US);

Changyou Zhou, Princeton, NJ (US);

Songnian Lin, Monroe, NJ (US);

Haifeng Tang, Metuchen, NJ (US);

Eric Dean Cline, Princeton, NJ (US);

Sunita Malkani, Lincoln Park, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/421 (2006.01); A61K 31/4245 (2006.01); A61K 31/426 (2006.01); A61K 31/4436 (2006.01); A61K 31/4725 (2006.01); A61K 31/443 (2006.01); A61K 31/4439 (2006.01); C07D 417/12 (2006.01); C07D 413/12 (2006.01); C07D 233/72 (2006.01); C07D 277/34 (2006.01); C07D 271/06 (2006.01); C07D 263/44 (2006.01);
U.S. Cl.
CPC ...
Abstract

Bicyclic compounds containing a phenyl or pyridyl ring fused to a cycloalkyl or heterocyclic ring, to which is attached a 5-membered heterocyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.


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