The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 20, 2010
Filed:
Mar. 18, 2009
Ming-yu Chen, Miaoli, TW;
Chin-kai Chuang, Hsinchu, TW;
Yu-hsyu Su, Miaoli, TW;
Chiu-ting Fan, Hsinchu County, TW;
Jung-chuan Yu, Hsinchu, TW;
Wen-chuan Lee, Hsinchu, TW;
Ming-Yu Chen, Miaoli, TW;
Chin-Kai Chuang, Hsinchu, TW;
Yu-Hsyu Su, Miaoli, TW;
Chiu-Ting Fan, Hsinchu County, TW;
Jung-Chuan Yu, Hsinchu, TW;
Wen-Chuan Lee, Hsinchu, TW;
Stresspro Biomedicine Incorporation, Hsinchu, TW;
Animal Technology Institute Taiwan, Miaoli Hsiem, TW;
Abstract
Expression system for enhancing solubility and immunogenicity of recombinant proteins. The expression system includes a protein expression vector that contains a chimeric gene encoding a chimeric protein comprising: (a) a first polypeptidyl fragment at the N-terminal end of the chimeric protein, containing a protein transduction domain (PTD), or a fragment thereof, having HIV Tat PTD activity; (b) a second polypeptidyl fragment at the C-terminal end of the first polypeptidyl fragment, containing a J-domain, or a fragment thereof, having heat shock protein 70 (Hsp70)-interacting activity; and (c) a third polypeptidyl fragment at the C-terminal end of the second polypeptidyl fragment, containing a target protein or polypeptide.