The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 20, 2010
Filed:
Jun. 04, 2004
Jay S. Tung, Belmont, CA (US);
Lee H. Latimer, Oakland, CA (US);
Jing Wu, Redwood City, CA (US);
Albert Garofalo, South San Francisco, CA (US);
Michael A. Pleiss, Sunnyvale, CA (US);
Darren Dressen, Fremont, CA (US);
Ashley Guinn, Santa Monica, CA (US);
Scott A. Jenkins, Tucson, AZ (US);
Jennifer Sealy, Oakland, CA (US);
John Tucker, San Diego, CA (US);
David W. G. Wone, Newark, CA (US);
Jay S. Tung, Belmont, CA (US);
Lee H. Latimer, Oakland, CA (US);
Jing Wu, Redwood City, CA (US);
Albert Garofalo, South San Francisco, CA (US);
Michael A. Pleiss, Sunnyvale, CA (US);
Darren Dressen, Fremont, CA (US);
Ashley Guinn, Santa Monica, CA (US);
Scott A. Jenkins, Tucson, AZ (US);
Jennifer Sealy, Oakland, CA (US);
John Tucker, San Diego, CA (US);
David W. G. Wone, Newark, CA (US);
Elan Pharmaceuticals, Inc., South San Francisco, CA (US);
Abstract
This invention is directed to acylated amino acid amidyl pyrazoles and related compounds of Formula I. The invention is also directed to a pharmaceutical formation comprising such compound or in a pharmaceutically acceptable salt form thereof. The invention is further directed to a method for inhibiting β-amyloid peptide release and/or synthesis, a method for inhibiting γ-secretase activity, and a method for treating neurological disorders associated with β-amyloid peptide production. The method comprises administering to a host a pharmaceutical formulation comprising an effective amount of a compound of Formula I. The compounds of Formula I are useful in the prevention and treatment of Alzheimer's disease.