The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 20, 2010
Filed:
Jul. 23, 2004
Applicants:
Peter A. Crooks, Nicholasville, KY (US);
Mohamed Omer Hamad, Lexington, KY (US);
Audra Lynn Stinchcomb, Lexington, KY (US);
Inventors:
Peter A. Crooks, Nicholasville, KY (US);
Mohamed Omer Hamad, Lexington, KY (US);
Audra Lynn Stinchcomb, Lexington, KY (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/485 (2006.01); C07D 489/09 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention is directed to forming duplex prodrugs that provide significant increase in the transdermal flux of drugs across human skin. The prodrugs are prepared by reacting a drug that can form an ester moiety with phosgene to form a carbonate. The drug can be an opiate or an opiate antagonist. When in contact with human skin, the duplex drug is biotransformed by enzymes or by hydrolysis into two drug molecules.