The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 20, 2010
Filed:
Jun. 12, 2006
Zhaoning Zhu, Plainsboro, NJ (US);
Brian Mckittrick, New Vernon, NJ (US);
Andrew Stamford, Chatham Township, NJ (US);
Ying Huang, East Brunswick, NJ (US);
Elizabeth M. Smith, Verona, NJ (US);
Zhaoning Zhu, Plainsboro, NJ (US);
Brian McKittrick, New Vernon, NJ (US);
Andrew Stamford, Chatham Township, NJ (US);
Ying Huang, East Brunswick, NJ (US);
Elizabeth M. Smith, Verona, NJ (US);
Schering Corporation, Kenilworth, NJ (US);
Abstract
The present application provides compounds of the Formula: and stereoisomers, tautomers, or pharmaceutically acceptable salts and solvates thereof, wherein U, W, R, R, R, Rand Rin each formula (when present) are as defined in the specification, and pharmaceutical compositions comprising such compounds. Also disclosed are methods of using such compounds and compositions to inhibit aspartyl protease, and to treat a variety of disease and indications including (but not limited) to cardiovascular disease and cognitive and neurodegenerative disease. The compounds of the present invention are disclosed for use alone or in combination with one or more additional active ingredients such as cholinesterase inhibitors and a muscarinic magonist and/or mantagonists.